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Article

Placement of leucine zipper motifs at the carboxyl terminus of HIV-1 protease significantly reduces virion production.

PloS one - 1 Jan 2012

Pan Yen-Yu, Wang Shiu-Mei, Huang Kuo-Jung, Chiang Chien-Cheng, Wang Chin-Tien

Abstract excerpt

Natural HIV-1 protease (PR) is homodimeric. Some researchers believe that interactions between HIV-1 Gag-Pol molecules trigger the activation of embedded PR (which mediates Gag and Gag-Pol cleavage), and that Gag-Pol assembly domains outside of PR may contribute to PR activation by influencing PR dimer interaction in a Gag-Pol context. To determine if the enhancement of PR dimer interaction facilitates PR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22396796
DOI: 10.1371/journal.pone.0032845
PMCID: PMC3291649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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