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Article

Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation.

Journal of virology - 1 Feb 2011

Lee Eun-Gyung, Roy Jacqueline, Jackson Dana, Clark Patrick, Boyer Paul L, Hughes Stephen H, Linial Maxine L

Abstract excerpt

Unlike orthoretroviruses, foamy retroviruses (FV) synthesize Pol independently of Gag. The FV Pol precursor is cleaved only once between reverse transcriptase (RT) and integrase (IN) by the protease (PR), resulting in a PR-RT and an IN protein. Only the Pol precursor, not the cleaved subunits, is packaged into virions. Like orthoretroviral PRs, FV PR needs to dimerize to be active. Previously, we showed that a...

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Identifiers

PMID: 21123385
DOI: 10.1128/JVI.01873-09
PMCID: PMC3028899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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