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Article

Differentiation and visualization of diverse cellular phenotypic responses in primary high-content screening.

Journal of biomolecular screening - 1 Jul 2012

Kümmel Anne, Selzer Paul, Siebert Daniela, Schmidt Isabel, Reinhardt Jürgen, Götte Marjo, Ibig-Rehm Yvonne, Parker Christian N, Gabriel Daniela

Abstract excerpt

High-throughput screening, based on subcellular imaging, has become a powerful tool in lead discovery. Through the generation of high-quality images, not only the specific target signal can be analyzed but also phenotypic changes of the whole cell are recorded. Yet analysis strategies for the exploration of high-content screening results, in a manner that is independent from predefined control phenotypes, are...

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Source

Identifiers

PMID: 22396475
DOI: 10.1177/1087057112439324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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