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Article

MeCP2 in the rostral striatum maintains local dopamine content critical for psychomotor control.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Apr 2015

Su San-Hua, Kao Fang-Chi, Huang Yi-Bo, Liao Wenlin

Abstract excerpt

Methyl-CpG binding protein 2 (MeCP2) is a chromatin regulator highly expressed in mature neurons. Mutations of MECP2 gene cause >90% cases of Rett syndrome, a neurodevelopmental disorder featured by striking psychomotor dysfunction. In Mecp2-null mice, the motor deficits are associated with reduc...

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Source

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Identifiers

PMID: 25878291
DOI: 10.1523/JNEUROSCI.4624-14.2015
PMCID: PMC6605173

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25878291-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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