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Article

Macrophage-specific transgenic expression of cholesteryl ester hydrolase attenuates hepatic lipid accumulation and also improves glucose tolerance in ob/ob mice.

American journal of physiology. Endocrinology and metabolism - 1 May 2012

Bie Jinghua, Zhao Bin, Marqueen Kathryn E, Wang Jing, Szomju Barbara, Ghosh Shobha

Abstract excerpt

Cellular cholesterol homeostasis is increasingly being recognized as an important determinant of the inflammatory status of macrophages, and a decrease in cellular cholesterol levels polarizes macrophages toward an anti-inflammatory or M2 phenotype. Cholesteryl ester hydrolase (CEH) catalyzes the hydrolysis of stored intracellular cholesteryl esters (CE) and thereby enhances free cholesterol efflux and reduces...

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Identifiers

PMID: 22395110
DOI: 10.1152/ajpendo.00511.2011
PMCID: PMC3361987

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LDLR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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