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Article

The Cannabinoid Receptor 2 Protects Against Alcoholic Liver Disease Via a Macrophage Autophagy-Dependent Pathway.

Scientific reports - 27 Jun 2016

Denaës Timothé, Lodder Jasper, Chobert Marie-Noële, Ruiz Isaac, Pawlotsky Jean-Michel, Lotersztajn Sophie, Teixeira-Clerc Fatima

Abstract excerpt

Kupffer cells, the resident macrophages of the liver, play a major role in the pathogenesis of alcoholic liver disease. We have previously demonstrated that CB2 receptor protects against alcoholic liver disease by inhibiting alcohol-induced inflammation and steatosis via the regulation of Kupffer cell activation. Here, we explored the mechanism underlying these effects and hypothesized that the anti-inflammatory...

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Identifiers

PMID: 27346657
DOI: 10.1038/srep28806
PMCID: PMC4921859

Genes

ATG5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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