Article
Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr.
American journal of physiology. Endocrinology and metabolism - 1 Mar 2008
Lloyd David J, McCormick Jocelyn, Helmering Joan, Kim Ki Won, Wang Minghan, Fordstrom Preston, Kaufman Stephen A, Lindberg Richard A, Véniant Murielle M
Abstract excerpt
The metabolic syndrome is a group of disorders including obesity, insulin resistance, atherogenic dyslipidemia, hyperglycemia, and hypertension. To date, few animal models have been described to recapitulate the phenotypes of the syndrome. In this study, we generated and characterized two lines of triple-knockout mice that are deficient in either apolipoprotein E (Apoe(-/-)) or low-density lipoprotein receptor...
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