Secreted enzyme uptake masks the in vivo phenotype of macrophage-specific lysosomal acid lipase deletion.

Abstract excerpt

BACKGROUND AND HYPOTHESIS: Lysosomal acid lipase (LAL) is so far the only known intracellular enzyme that is capable of hydrolyzing triglycerides and cholesteryl esters at an acidic pH inside the lysosome. Mutations in the LAL-encoding Lipa gene cause a rare autosomal recessive lysosomal storage disorder in humans with massive lipid accumulation. In mice, the loss of systemic LAL is associated with severe lipid...

Topics

• Animals
• Sterol Esterase
• Macrophages
• Mice
• Mice, Knockout
• Phenotype
• Liver
• Lipid Metabolism
• Mice, Inbred C57BL
• Lysosomes
• Diet, High-Fat
• Male
• Obesity
• Triglycerides