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Article

Restoration of gallstone susceptibility by leptin in C57BL/6J ob/ob mice.

Journal of lipid research - 1 Jun 2003

Hyogo Hideyuki, Roy Suheeta, Cohen David E

Abstract excerpt

The absence of leptin due to the ob mutation leads to obesity and confers resistance to diet-induced cholesterol gallstone formation in otherwise susceptible C57BL/6J mice. To investigate contributions of obesity and leptin to gallstone susceptibility, C57BL/6J ob/ob mice were treated daily with i.p. saline or recombinant murine leptin at low (1 microgram/g bw) or high (10 microgram/g bw) doses and were pair-fed...

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Source

Identifiers

PMID: 12671032
DOI: 10.1194/jlr.M300029-JLR200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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