Article
Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression.
Archives of general psychiatry - 1 Jul 2012
Agrawal Arpana, Nelson Elliot C, Littlefield Andrew K, Bucholz Kathleen K, Degenhardt Louisa, Henders Anjali K, Madden Pamela A F, Martin Nicholas G, Montgomery Grant W, Pergadia Michele L, Sher Kenneth J, Heath Andrew C, Lynskey Michael T
Abstract excerpt
CONTEXT: The endocannabinoid system has been implicated in stress adaptation and the regulation of mood in rodent studies, but few human association studies have examined these links and replications are limited. OBJECTIVES: To examine whether a synonymous polymorphism, rs1049353, in exon 4 of the gene encoding the human endocannabinoid receptor (CNR1) moderates the effect of self-reported childhood physical...
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