Article
CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2009
Juhasz Gabriella, Chase Diana, Pegg Emma, Downey Darragh, Toth Zoltan G, Stones Kathryn, Platt Hazel, Mekli Krisztina, Payton Antony, Elliott Rebecca, Anderson Ian M, Deakin J F William
Abstract excerpt
Cannabinoid receptor 1 (CB1) gene (CNR1) knockout mice are prone to develop anhedonic and helpless behavior after chronic mild stress. In humans, the CB1 antagonist rimonabant increases the risk of depressed mood disorders and anxiety. These studies suggest the hypothesis that genetic variation in CB1 receptor function influences the risk of depression in humans in response to stressful life events. In a...
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