Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2006

Herman Aryeh I, Kranzler Henry R, Cubells Joseph F, Gelernter Joel, Covault Jonathan

Abstract excerpt

An alternative promoter producing a novel 5'-untranslated region of cannabinoid receptor mRNA has recently been described in CNR1, the gene encoding the cannabinoid receptor protein. Single nucleotide polymorphisms (SNPs) adjacent to this site were reported to be associated with polysubstance abuse [Zhang et al., 2004]. We examined the association of 4 SNPs (rs6928499, rs806379, rs1535255, rs2023239) in the...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Black or African American
Share to Exons
Share to Gene Frequency
Share to Promoter Regions, Genetic
Share to Receptor, Cannabinoid, CB1
Share to Substance-Related Disorders
Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 16741937
DOI: 10.1002/ajmg.b.30325
PMCID: PMC2574012

Genes

CNR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence.PMID 16741937Read ↗

Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse.Semantic proximity Read ↗

Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.Semantic proximity Read ↗

CNR1 variation modulates risk for drug and alcohol dependence.Semantic proximity Read ↗

CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis.Semantic proximity Read ↗

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.Semantic proximity Read ↗

Cannabinoid receptor 1 gene association with nicotine dependence.Semantic proximity Read ↗

Rare nonsynonymous exonic variants in addiction and behavioral disinhibition.Semantic proximity Read ↗

The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults.Semantic proximity Read ↗

Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.Semantic proximity Read ↗

Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.Semantic proximity Read ↗

Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression.Semantic proximity Read ↗

Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.