A functional neuregulin-1 gene variant and stressful life events: Effect on drug use in a longitudinal population-representative cohort study.

doi:10.1177/0269881116655979

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Article

A functional neuregulin-1 gene variant and stressful life events: Effect on drug use in a longitudinal population-representative cohort study.

Journal of psychopharmacology (Oxford, England) - 1 Jan 2017

Vaht Mariliis, Laas Kariina, Kiive Evelyn, Parik Jüri, Veidebaum Toomas, Harro Jaanus

Abstract excerpt

BACKGROUND: The neuregulin 1 gene is a susceptibility gene for substance dependence. A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use. This study assessed the...

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PMID: 27353026
DOI: 10.1177/0269881116655979

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NRG1

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