Article
The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jul 2012
Sapru A, Zaroff J G, Pawlikowska L, Liu K D, Khush K K, Baxter-Lowe L A, Hayden V, Menza R L, Convery M, Lo V, Poon A, Kim H, Young W L, Kukreja J, Matthay M A
Abstract excerpt
Widespread thrombi are found among donor lungs rejected for transplantation. The 4G/5G polymorphism in the plasminogen activator inhibitor (PAI-1) gene impacts transcription and the 4G allele is associated with increased PAI-1 levels. We hypothesized that the 4G/4G genotype would be associated with decreased lung graft utilization, potentially because of worse oxygenation in the donor. We genotyped donors managed...
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