Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDS.

Thrombosis research - 1 Apr 2009

Tsangaris Iraklis, Tsantes Argiris, Bonovas Stefanos, Lignos Michalis, Kopterides Petros, Gialeraki Argiro, Rapti Evdoxia, Orfanos Stylianos, Dimopoulou Ioanna, Travlou Anthi, Armaganidis Apostolos

Abstract excerpt

INTRODUCTION: Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been associated with worse outcome in ALI/ARDS. A single guanosine insertion/deletion (4G/5G) polymorphism in the promoter region of the PAI-1 gene, may play an important role in the regulation of PAI-1 expression. The objective of the study was to evaluate the effect of this polymorphism on the outcome of critically ill patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Plasminogen Activator Inhibitor 1
Share to Acute Lung Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bronchoalveolar Lavage Fluid

Share to Homozygote

Share to INDEL Mutation

Share to Prognosis

Share to Respiration, Artificial

Share to Respiratory Distress Syndrome

Source

Identifiers

PMID: 18804848
DOI: 10.1016/j.thromres.2008.07.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDS.PMID 18804848Read ↗

4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic studySemantic proximity Read ↗

Genetics of acute lung injury: past, present and future.Semantic proximity Read ↗

4G/5G PAI-1 promoter polymorphism and acute-phase levels of PAI-1 following coronary bypass surgery: a prospective study.Semantic proximity Read ↗

Role of 4G/5G plasminogen activator inhibitor-1 (PAI-1) gene polymorphism and the PAI-1 plasma levels in the outcome of patients with severe sepsisSemantic proximity Read ↗

4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia.Semantic proximity Read ↗

Plasminogen activator inhibitor-1 and asthma: role in the pathogenesis and molecular regulation.Semantic proximity Read ↗

PAI-1 genetic polymorphisms influence septic patients' outcomes by regulating neutrophil activity.Semantic proximity Read ↗

The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization.Semantic proximity Read ↗

Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome.Semantic proximity Read ↗

Plasminogen Activator Inhibitor Type 1 Gene Polymorphism and SepsisSemantic proximity Read ↗

Pre-B-cell colony-enhancing factor gene polymorphisms and risk of acute respiratory distress syndrome.Semantic proximity Read ↗

Plasminogen activator inhibitor I 4G/5G polymorphism in neonatal respiratory distress syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.