Article
Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Feb 2011
Sapru Anil, Pawlikowska Ludmila, Liu Kathleen D, Khush Kiran K, Ann-Baxter-Lowe Lee, Hayden Vanessa, Menza Rebecca L, Convery Maureen, Poon Annie, Landeck Megan, Zaroff Jonathan G, Matthay Michael A
Abstract excerpt
BACKGROUND: Pulmonary edema and associated impaired oxygenation are a major reason for rejection of donor lung allografts offered for transplantation. Clearance of pulmonary edema can be upregulated by stimulation of β-adrenergic receptors (βARs). Single-nucleotide polymorphisms (SNPs) in βAR genes have functional effects in vitro and in vivo. We hypothesized that SNPs in βAR genes would be associated with rates...
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