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Article

PAI-1 gene: pharmacogenetic association of 4G/4G genotype with bleeding after cardiac surgery--pilot study.

European journal of anaesthesiology - 1 May 2009

Sirgo Gonzalo, Morales Pablo, Rello Jordi

Abstract excerpt

BACKGROUND AND OBJECTIVE: To investigate whether the 4G/4G genotype of the PAI-1 gene is associated with bleeding after cardiac surgery and whether it may influence the use of antifibrinolytic drugs. METHODS: After a case-control association study to compare the distribution of genotypes of the 4G/5G polymorphism of the PAI-1 gene (4G/4G, 4G/5G and 5G/5G) between cardiac surgery patients (n = 260) and...

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PMID: 19521296
DOI: 10.1097/EJA.0b013e3283240412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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