Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia.

American journal of respiratory and critical care medicine - 1 Dec 2007

Yende Sachin, Angus Derek C, Ding Jingzhong, Newman Anne B, Kellum John A, Li Rongling, Ferrell Robert E, Zmuda Joseph, Kritchevsky Stephen B, Harris Tamara B, Garcia Melissa, Yaffe Kristine, Wunderink Richard G

Abstract excerpt

RATIONALE: Plasminogen activator inhibitor (PAI)-1 inhibits urokinase and tissue plasminogen activator, required for host response to infection. Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown. OBJECTIVES: To ascertain the role of the 4G/5G polymorphism and other genetic variants within the PAI-1 gene. We hypothesized that variants associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood
Share to Community-Acquired Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipopolysaccharides

Share to Longitudinal Studies

Share to Osmolar Concentration

Share to Peptidoglycan

Share to Plasminogen Activator Inhibitor 1

Share to Pneumonia

Source

Open in PubMed Open full text

Identifiers

PMID: 17761618
DOI: 10.1164/rccm.200605-644OC
PMCID: PMC2176102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia.PMID 17761618Read ↗

4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic studySemantic proximity Read ↗

Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke.Semantic proximity Read ↗

Plasminogen activator inhibitor 4G polymorphism is associated with decreased risk of cerebrovascular mortality in older women.Semantic proximity Read ↗

The influence of 4G/5G polymorphism in the plasminogen-activator-inhibitor-1 promoter on COVID-19 severity and endothelial dysfunction.Semantic proximity Read ↗

Plasminogen activator inhibitor type-1 (PAI-1) polymorphism 4G/5G is associated with prostate cancer among men with a positive family history.Semantic proximity Read ↗

The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals.Semantic proximity Read ↗

Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference.Semantic proximity Read ↗

PAI-1 4G/5G polymorphism contributes to cancer susceptibility: evidence from meta-analysis.Semantic proximity Read ↗

Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels.Semantic proximity Read ↗

Association Between Plasminogen Activator Inhibitor-1-675 4G/5G Insertion/Deletion Polymorphism and Chronic Obstructive Pulmonary Disease.Semantic proximity Read ↗

A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia.Semantic proximity Read ↗

Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and PAI-1 plasma levels in young patients with ischemic stroke.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.