Inositol 1,4,5-trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phosphoregulation of microtubule binding affinity.

doi:10.1074/jbc.M112.344101

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Article

Inositol 1,4,5-trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phosphoregulation of microtubule binding affinity.

The Journal of biological chemistry - 4 May 2012

Lee Dongmin, Lee Hyun Woo, Hong Soontaek, Choi Byung-Il, Kim Hyun-Wook, Han Seung Baek, Kim Il Hwan, Bae Jin Young, Bae Yong Chul, Rhyu Im Joo, Sun Woong, Kim Hyun

Abstract excerpt

Inositol 1,4,5-trisphosphate 3-kinase A (IP(3)K-A) is a brain specific and F-actin-binding protein. We recently demonstrated that IP(3)K-A modulates a structural reorganization of dendritic spines through F-actin remodeling, which is required for synaptic plasticity and memory formation in brain. However, detailed functions of IP(3)K-A and its regulatory mechanisms involved in the neuronal cytoskeletal dynamics...

Topics

Animals
Binding, Competitive
Cells, Cultured
Cyclic AMP-Dependent Protein Kinases
Dendrites
Green Fluorescent Proteins
HEK293 Cells
Hippocampus
Humans
Immunoblotting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microscopy, Immunoelectron

Microtubule-Associated Proteins

Microtubules

Mutation

Neurons

Phosphorylation

Phosphotransferases (Alcohol Group Acceptor)

Source

Open in PubMed Open full text

Identifiers

PMID: 22389500
DOI: 10.1074/jbc.M112.344101
PMCID: PMC3346136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22389500-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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