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Article

Lipid accumulation in adipose tissue-resident iNKT cells contributes to an inflammatory phenotype.

Adipocyte - 1 Dec 2024

Morris Imogen, Vrieling Frank, Bouwman Annemieke, Stienstra Rinke, Kalkhoven Eric

Abstract excerpt

Reciprocal communication between adipocytes and immune cells is essential to maintain optimal adipose tissue (AT) functionality. Amongst others, adipocytes directly interact with invariant NKT cells (iNKT cells), which in turn secrete various cytokines. A lipid-rich microenvironment, as observed in obesity, skews this adipocyte-driven cytokine output towards a more inflammatory output. Whether a lipid-rich...

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Identifiers

PMID: 39484712
DOI: 10.1080/21623945.2024.2421750
PMCID: PMC11540091

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