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Article

Isocitrate dehydrogenase mutation hot spots in acute lymphoblastic leukemia and oral cancer.

The Kaohsiung journal of medical sciences - 1 Mar 2012

Tang Jen-Yang, Chang Chun-Chi, Lin Pei-Chin, Chang Jan-Gowth

Abstract excerpt

Isocitrate dehydrogenase (IDH) encodes a nicotinamide adenine dinucleotide phosphate+-dependent enzyme for oxidative decarboxylation of isocitrate and has an essential role in the tricarboxylic acid cycle. Mutations of IDH1 and IDH2 have been identified in patients with glioma, leukemia, and other cancers. However, the incidence of IDH mutations in acute myeloid leukemia in Taiwan is much lower than that reported...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22385606
DOI: 10.1016/j.kjms.2011.10.023

Genes

IDH2
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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