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Article

Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition.

PloS one - 1 Jan 2012

Gulati Ajay S, Shanahan Michael T, Arthur Janelle C, Grossniklaus Emily, von Furstenberg Richard J, Kreuk Lieselotte, Henning Susan J, Jobin Christian, Sartor R Balfour

Abstract excerpt

BACKGROUND: Increasing evidence supports the central role of Paneth cells in maintaining intestinal host-microbial homeostasis. However, the direct impact of host genotype on Paneth cell function remains unclear. Here, we characterize key differences in Paneth cell function and intestinal microbial composition in two widely utilized, genetically distinct mouse strains (C57BL/6 and 129/SvEv). In doing so, we...

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Identifiers

PMID: 22384242
DOI: 10.1371/journal.pone.0032403
PMCID: PMC3288091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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