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Article

A Strong Impact of Genetic Background on Gut Microflora in Mice

1 Jan 2010

Abstract excerpt

Genetic background affects susceptibility to ileocolitis in mice deficient in two intracellular glutathione peroxidases, GPx1 and GPx2. The C57BL/6 (B6) GPx1/2 double-knockout (DKO) mice have mild ileocolitis, and 129S1/Sv (129) DKO mice have severe inflammation. We used diet to modulate ileocolitis; a casein-based defined diet with AIN76A micronutrients (AIN) attenuates inflammation compared to conventional...

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PMID: 20976020
DOI: 10.4061/2010/986046

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