Back to search

Article

Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10 <sup>-/-</sup> mouse model of inflammatory bowel disease

2023-01-27

Abstract excerpt

<h4>Background</h4> Following viral infection, genetically manipulated mice lacking immunoregulatory function may develop colitis and dysbiosis in a strain specific fashion that serves as a model for inflammatory bowel disease (IBD). We found that one such model of spontaneous colitis, the interleukin (IL)-10 knockout (IL-I0 -/- ) model derived from the SvEv mouse, had evidence of increased mouse mammary tumor v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1432ed7c-8704-579a-8bdb-2030a2f9b9c6
DOI
10.1101/2023.01.26.525771
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10 <sup>-/-</sup> mouse model of inflammatory bowel diseaseDOI 10.1101/2023.01.26.525771
Induction of mastitis by cow-to-mouse fecal and milk microbiota transplantation causes microbiome dysbiosis and genomic functional perturbation in miceSemantic proximity
Endogenous Mouse Mammary Tumor Viruses (Mtv): New Roles for an Old Virus in Cancer, Infection, and ImmunitySemantic proximity
Activation, control and T-bet+ B cell-mediated immune surveillance of endogenous retrovirusesSemantic proximity
Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.Semantic proximity
Generation and Phenotypic Analysis of the IL-10RAR104W/R104W Mouse Model.Semantic proximity
Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.Semantic proximity
Modeling Infectious Disease in Mice: Co-Adaptation and the Role of Host-Specific IFNγ ResponsesSemantic proximity
Metaproteomics of colonic microbiota unveils discrete protein functions among colitic mice and control groupsSemantic proximity
Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse ModelSemantic proximity
Differential Responses of Lung and Intestinal Microbiota to SARS-CoV-2 Infection: A Comparative Study of the Wuhan and Omicron Strains in K18-hACE2 tg MiceSemantic proximity
A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice.Semantic proximity
Exposing New Taxonomic Variation with Inflammation – A Murine Model-Specific Genome Database for Gut Microbiome ResearchersSemantic proximity
Select a neighboring publication to make it the new centre.