Article
MCP1 SNPs and pulmonary tuberculosis in cohorts from West Africa, the USA and Argentina: lack of association or epistasis with IL12B polymorphisms.
PloS one - 1 Jan 2012
Velez Edwards Digna R, Tacconelli Alessandra, Wejse Christian, Hill Philip C, Morris Gerard A J, Edwards Todd L, Gilbert John R, Myers Jamie L, Park Yo Son, Stryjewski Martin E, Abbate Eduardo, Estevan Rosa, Rabna Paulo, Novelli Giuseppe, Hamilton Carol D, Adegbola Richard, Østergaar Lars, Williams Scott M, Scott William K, Sirugo Giorgio
Abstract excerpt
The monocyte chemotactic protein-1 (MCP-1) is a chemokine that plays an important role in the recruitment of monocytes to M. tuberculosis infection sites, and previous studies have reported that genetic variants in MCP1 are associated with differential susceptibility to pulmonary tuberculosis (PTB). We examined eight MCP1 single nucleotide polymorphisms (SNPs) in a multi-ethnic, case-control design that included:...
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