Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: a study of cohorts from The Gambia, Guinea-Bissau, United States and Argentina.

doi:10.1371/journal.pone.0016656

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Article

Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: a study of cohorts from The Gambia, Guinea-Bissau, United States and Argentina.

PloS one - 9 Feb 2011

Morris Gerard A J, Edwards Digna R Velez, Hill Philip C, Wejse Christian, Bisseye Cyrille, Olesen Rikke, Edwards Todd L, Gilbert John R, Myers Jamie L, Stryjewski Martin E, Abbate Eduardo, Estevan Rosa, Hamilton Carol D, Tacconelli Alessandra, Novelli Giuseppe, Brunetti Ercole, Aaby Peter, Sodemann Morten, Østergaard Lars, Adegbola Richard, Williams Scott M, Scott William K, Sirugo Giorgio

Abstract excerpt

We examined whether polymorphisms in interleukin-12B (IL12B) associate with susceptibility to pulmonary tuberculosis (PTB) in two West African populations (from The Gambia and Guinea-Bissau) and in two independent populations from North and South America. Nine polymorphisms (seven SNPs, one insertion/deletion, one microsatellite) were analyzed in 321 PTB cases and 346 controls from Guinea-Bissau and 280 PTB cases...

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PMID: 21339808
DOI: 10.1371/journal.pone.0016656
PMCID: PMC3037276

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