Article
A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.
The Journal of experimental medicine - 19 Dec 2005
Flores-Villanueva Pedro O, Ruiz-Morales Jorge A, Song Chang-Hwa, Flores Ludmila M, Jo Eun-Kyeong, Montaño Marta, Barnes Peter F, Selman Moises, Granados Julio
Abstract excerpt
We examined the distribution of single nucleotide polymorphisms (SNPs) in nitric oxide synthase 2A, monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T cell expressed and secreted, and macrophage inflammatory protein-1alpha genes in tuberculosis patients and healthy controls from Mexico. The odds of developing tuberculosis were 2.3- and 5.4-fold higher in carriers of MCP-1 genotypes AG...
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