Article
Allele-specific induction of IL-1β expression by C/EBPβ and PU.1 contributes to increased tuberculosis susceptibility.
PLoS pathogens - 1 Oct 2014
Zhang Guoliang, Zhou Boping, Li Shaoyuan, Yue Jun, Yang Hui, Wen Yuxin, Zhan Senlin, Wang Wenfei, Liao Mingfeng, Zhang Mingxia, Zeng Gucheng, Feng Carl G, Sassetti Christopher M, Chen Xinchun
Abstract excerpt
Mycobacterium tuberculosis infection is associated with a spectrum of clinical outcomes, from long-term latent infection to different manifestations of progressive disease. Pro-inflammatory pathways, such as those controlled by IL-1β, have the contrasting potential both to prevent disease by rest...
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