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Article

Kv1.3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2012

Cidad Pilar, Jiménez-Pérez Laura, García-Arribas Daniel, Miguel-Velado Eduardo, Tajada Sendoa, Ruiz-McDavitt Christian, López-López José R, Pérez-García M Teresa

Abstract excerpt

OBJECTIVE: Phenotypic modulation of vascular smooth muscle cells has been associated with a decreased expression of all voltage-dependent potassium channel (Kv)1 channel encoding genes but Kcna3 (which encodes Kv1.3 channels). In fact, upregulation of Kv1.3 currents seems to be important to modulate proliferation of mice femoral vascular smooth muscle cells in culture. This study was designed to explore if these...

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Identifiers

PMID: 22383699
DOI: 10.1161/ATVBAHA.111.242727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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