Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery.

Abstract excerpt

Inwardly rectifying K(+) (K(IR)) currents are present in some, but not all, vascular smooth muscles. We used patch-clamp methods to examine plasticity of this current by comparing contractile and proliferative phenotypes of a clonal human vascular smooth muscle cell line. Hyperpolarization of cells under voltage clamp elicited a large inward current that was selective for K(+) and blocked by Ba(2+). Current...

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