Article
Kv1.3 channels modulate human vascular smooth muscle cells proliferation independently of mTOR signaling pathway.
Pflugers Archiv : European journal of physiology - 1 Aug 2015
Cidad Pilar, Miguel-Velado Eduardo, Ruiz-McDavitt Christian, Alonso Esperanza, Jiménez-Pérez Laura, Asuaje Agustín, Carmona Yamila, García-Arribas Daniel, López Javier, Marroquín Yngrid, Fernández Mirella, Roqué Mercè, Pérez-García M Teresa, López-López José Ramón
Abstract excerpt
Phenotypic modulation (PM) of vascular smooth muscle cells (VSMCs) is central to the process of intimal hyperplasia which constitutes a common pathological lesion in occlusive vascular diseases. Changes in the functional expression of Kv1.5 and Kv1.3 currents upon PM in mice VSMCs have been found to contribute to cell migration and proliferation. Using human VSMCs from vessels in which unwanted remodeling is a...
Topics
- Cell Proliferation
- Cells, Cultured
- Humans
- Kv1.3 Potassium Channel
- Kv1.5 Potassium Channel
- Membrane Potentials
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle
- Phenotype