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Article

Reduced expression of KCNMB1 leads to vascular smooth muscle cell phenotypic switch and apoptosis.

Biochemical pharmacology - 1 Nov 2025

Liu Hongshan, Zhou Xinyuan, Zhang Jiaxiang, Zuo Bojing, Wang Ge, Guo Ziyu, Zhang Jin, Huang Haixia, Wang Wei, Wang Meili

Abstract excerpt

BK channel, the large conductance calcium-activated potassium channel, plays an important role in negative feedback regulation of membrane potential and relaxation in vascular smooth muscle cells (VSMCs) due to its high conductance, voltage and calcium sensitivity. However, the role of the BK channel in VSMC fate, particularly during the chronic process of cardiovascular disease (CVD) development, is not fully...

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PMID: 40653026
DOI: 10.1016/j.bcp.2025.117151

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