Article
Eukaryotic class 1 translation termination factor eRF1--the NMR structure and dynamics of the middle domain involved in triggering ribosome-dependent peptidyl-tRNA hydrolysis.
The FEBS journal - 1 Aug 2007
Ivanova Elena V, Kolosov Peter M, Birdsall Berry, Kelly Geoff, Pastore Annalisa, Kisselev Lev L, Polshakov Vladimir I
Abstract excerpt
The eukaryotic class 1 polypeptide chain release factor is a three-domain protein involved in the termination of translation, the final stage of polypeptide biosynthesis. In attempts to understand the roles of the middle domain of the eukaryotic class 1 polypeptide chain release factor in the transduction of the termination signal from the small to the large ribosomal subunit and in peptidyl-tRNA hydrolysis, its...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Binding Sites
- Eukaryotic Cells
- Hydrolysis
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptide Chain Termination, Translational
- Peptide Termination Factors
- Protein Binding