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Article

PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.

Experimental cell research - 10 Dec 2011

Hiwatashi Yusuke, Kanno Kohei, Takasaki Chikahisa, Goryo Kenji, Sato Takuya, Torii Satoru, Sogawa Kazuhiro, Yasumoto Ken-ichi

Abstract excerpt

Cellular response to hypoxia plays an important role in both circulatory and pulmonary diseases and cancer. Hypoxia-inducible factors (HIFs) are major transcription factors regulating the response to hypoxia. The α-subunits of HIFs are hydroxylated by members of the prolyl-4-hydroxylase domain (PHD) family, PHD1, PHD2, and PHD3, in an oxygen-dependent manner. Here, we report on the identification of ATF4 as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

Identifiers

PMID: 21951999
DOI: 10.1016/j.yexcr.2011.09.005

Genes

ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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