Article
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.
Molecular cell - 1 Dec 2000
Ye J, Rawson R B, Komuro R, Chen X, Davé U P, Prywes R, Brown M S, Goldstein J L
Abstract excerpt
ATF6 is a membrane-bound transcription factor that activates genes in the endoplasmic reticulum (ER) stress response. When unfolded proteins accumulate in the ER, ATF6 is cleaved to release its cytoplasmic domain, which enters the nucleus. Here, we show that ATF6 is processed by Site-1 protease (S1P) and Site-2 protease (S2P), the enzymes that process SREBPs in response to cholesterol deprivation. ATF6 processing...
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