Article
E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1.
Molecular biology of the cell - 1 Sept 2008
Yang Wei-Wei, Shu Bo, Zhu Yi, Yang Huang-Tian
Abstract excerpt
E2F6, a potent transcriptional repressor, plays important roles in cell cycle regulation. However, roles of E2F6 in hypoxia-induced apoptosis are unknown. Here, we demonstrated biological functions of E2F6 in hypoxia-induced apoptosis and regulatory pathways. During hypoxia (CoCl(2), 800 microM)-induced human embryonic kidney 293 cell apoptosis, E2F6 expression was down-regulated with concurrent increases in E2F1...
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