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Article

Methyl Donor Deficiency Blocks Colorectal Cancer Development by Affecting Key Metabolic Pathways.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2020

Hanley Matthew P, Aladelokun Oladimeji, Kadaveru Krishna, Rosenberg Daniel W

Abstract excerpt

Our understanding of the role of folate one-carbon metabolism in colon carcinogenesis remains incomplete. Previous studies indicate that a methyl donor-deficient (MDD) diet lacking folic acid, choline, methionine, and vitamin B12 is associated with long-lasting changes to the intestinal epithelium and sustained tumor protection in Apc-mutant mice. However, the metabolic pathways by which the MDD diet affects...

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Identifiers

PMID: 31748255
DOI: 10.1158/1940-6207.CAPR-19-0188
PMCID: PMC6954304

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