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Suppression of the Epithelial–Mesenchymal Transition by Grainyhead-like-2

29 Feb 2012

Abstract excerpt

Grainyhead genes are involved in wound healing and developmental neural tube closure. In light of the high degree of similarity between the epithelial-mesenchymal transitions (EMT) occurring in wound-healing processes and the cancer stem cell-like compartment of tumors, including TGF-β dependence, we investigated the role of the Grainyhead gene, Grainyhead-like-2 (GRHL2) in oncogenic EMT. GRHL2 was downregulated...

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PMID: 22379025
DOI: 10.1158/0008-5472.can-11-4038

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