Article
Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells.
Cell cycle (Georgetown, Tex.) - 3 Apr 2017
Faddaoui Adnen, Sheta Razan, Bachvarova Magdalena, Plante Marie, Gregoire Jean, Renaud Marie-Claude, Sebastianelli Alexandra, Gobeil Stephane, Morin Chantale, Ghani Karim, Bachvarov Dimcho
Abstract excerpt
Previously, we have identified the Grainyhead transcription factor 2 gene (GRHL2) as notably hypomethylated in high-grade (HG) serous epithelial ovarian tumors, compared with normal ovarian tissues. GRHL2 is known for its functions in normal tissue development and wound healing. In the context of cancer, the role of GRHL2 is still ambiguous as both tumorigenic and tumor suppressive functions have been reported...
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