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The GRHL2/ZEB Feedback Loop-A Key Axis in the Regulation of EMT in Breast Cancer

7 Mar 2017

Abstract excerpt

More than 90% of cancer-related deaths are caused by metastasis. Epithelial-to-Mesenchymal Transition (EMT) causes tumor cell dissemination while the reverse process, Mesenchymal-to-Epithelial Transition (MET) allows cancer cells to grow and establish a potentially deadly metastatic lesion. Recent evidence indicates that in addition to E and M, cells can adopt a stable hybrid Epithelial/Mesenchymal (E/M) state...

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PMID: 28266048
DOI: 10.1002/jcb.25974

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