Article

Effect of TIMPs and Their Minimally Engineered Variants in Blocking Invasion and Migration of Brain Cancer Cells

2024-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Matrix metalloproteinases (MMPs) play a pivotal role in extracellular matrix (ECM) remodeling, influencing various aspects of cancer progression including migration, invasion, angiogenesis, and metastasis. Overexpression of MMPs, particularly MMP-2 and MMP-9, is notably pronounced in glioblastoma multiforme (GBM), a highly aggressive primary brain tumor characterized by diffuse and infiltrative...

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Literature Corpus work: ef41ee6e-78d8-500f-9b16-7efc703cec99
DOI: 10.1101/2024.06.05.597644

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