Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ADAM17 promotes glioma cell malignant phenotype.

Molecular carcinogenesis - 1 Feb 2012

Zheng Xuguang, Jiang Feng, Katakowski Mark, Lu Yong, Chopp Michael

Abstract excerpt

A disintegrin and metalloproteinase-17 (ADAM17) is involved in proteolytic ectodomain shedding of several membrane-bound growth factors and cytokines. The expression and activity of ADAM17 increase under some pathological conditions such as stroke and cancer. ADAM17 promotes neural progenitor cell migration and contributes to neurogenesis after stroke and breast cancer growth and invasion. In the present study,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to ADAM17 Protein
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Neoplasms

Share to Glioma

Share to Mice, Nude

Share to RNA, Small Interfering

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 21480393
DOI: 10.1002/mc.20772
PMCID: PMC3234333

Genes

ADAM17
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADAM17 promotes glioma cell malignant phenotype.PMID 21480393Read ↗

ADAMTS8 inhibits glioma development in vitro and in vivoSemantic proximity Read ↗

Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming CellsSemantic proximity Read ↗

Effects of tetrandrine on glioma cell malignant phenotype via inhibition of ADAM17.Semantic proximity Read ↗

The Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its AggressivenessSemantic proximity Read ↗

ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21Semantic proximity Read ↗

ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistanceSemantic proximity Read ↗

A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 SignalingSemantic proximity Read ↗

Molecular switch in human diseases-disintegrin and metalloproteinases, ADAM17Semantic proximity Read ↗

A novel program of infiltrative control in astrocytomas: ADAM23 depletion promotes cell invasion by activating γ-Secretase and NOTCH1 signaling pathwaySemantic proximity Read ↗

ADAMs in cancer cell proliferation and progressionSemantic proximity Read ↗

Increased Expression of microRNA-17 Predicts Poor Prognosis in Human GliomaSemantic proximity Read ↗

An Overview of ADAM9: Structure, Activation, and Regulation in Human DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.