Article
Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2.
Cancer letters - 28 Jan 2021
Si Wenxia, Zhou Bisheng, Xie Wen, Li Hui, Li Ke, Li Sisi, Deng Wenbing, Shi Pengcheng, Yuan Chao, Ke Tie, Ren Xiang, Tu Xin, Zeng Xiaomei, Weigelt Britta, Rubin Brian P, Chen Qiuyun, Xu Chengqi, Wang Qing Kenneth
Abstract excerpt
Angiogenesis factors are widely known to promote tumor growth by increasing tumor angiogenesis in the tumor microenvironment, however, little is known whether their intracellular function is involved in tumorigenesis. Here we show that AGGF1 acts as a tumor suppressor by regulating p53 when acting inside tumor cells. AGGF1 antagonizes MDM2 function to inhibit p53 ubiquitination, increases the acetylation,...
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