Article
miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma.
Cancer research - 1 Jul 2013
Wei Jun, Wang Fei, Kong Ling-Yuan, Xu Shuo, Doucette Tiffany, Ferguson Sherise D, Yang Yuhui, McEnery Kayla, Jethwa Krishan, Gjyshi Olsi, Qiao Wei, Levine Nicholas B, Lang Frederick F, Rao Ganesh, Fuller Gregory N, Calin George A, Heimberger Amy B
Abstract excerpt
miRNAs (miR) have been shown to modulate critical gene transcripts involved in tumorigenesis, but their role in tumor-mediated immunosuppression is largely unknown. On the basis of miRNA gene expression in gliomas using tissue microarrays, in situ hybridization, and molecular modeling, miR-124 was identified as a lead candidate for modulating STAT3 signaling, a key pathway mediating immunosuppression in the tumor...
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