Matrix metalloproteinase-1 expression enhances tumorigenicity as well as tumor-related angiogenesis and is inversely associated with TIMP-4 expression in a model of glioblastoma.

doi:10.1007/s11060-011-0691-5

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Article

Matrix metalloproteinase-1 expression enhances tumorigenicity as well as tumor-related angiogenesis and is inversely associated with TIMP-4 expression in a model of glioblastoma.

Journal of neuro-oncology - 1 Feb 2012

Pullen Nicholas A, Anand Monika, Cooper Patricia S, Fillmore Helen L

Abstract excerpt

Herein we continue the study of matrix metalloproteinase-1 (MMP-1) with respect to glioblastoma multiforme (GBM) cell tumorigenicity and angiogenesis. A model of tumorigenicity with cells stably altered to over-express or knock-down MMP-1 revealed that it significantly increases tumor incidence and size. Organized endothelial growth in human umbilical vein endothelial cell (HUVEC)-GBM co-cultures was...

Topics

Animals
Brain Neoplasms
Cell Line, Tumor
Cell Transformation, Neoplastic
Coculture Techniques
Disease Models, Animal
Endothelial Cells
Gene Expression Regulation, Neoplastic
Glioblastoma
Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Matrix Metalloproteinase 1

Mice

Mice, Nude

Mutation

Neovascularization, Pathologic

Platelet Endothelial Cell Adhesion Molecule-1

Proteomics

Source

Open in PubMed

Identifiers

PMID: 21858729
DOI: 10.1007/s11060-011-0691-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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