Article
Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation.
Nucleic acids research - 1 Jul 2012
Andreev Dmitri E, Hirnet Juliane, Terenin Ilya M, Dmitriev Sergey E, Niepmann Michael, Shatsky Ivan N
Abstract excerpt
Adaptation to the host cell environment to efficiently take-over the host cell's machinery is crucial in particular for small RNA viruses like picornaviruses that come with only small RNA genomes and replicate exclusively in the cytosol. Their Internal Ribosome Entry Site (IRES) elements are specific RNA structures that facilitate the 5' end-independent internal initiation of translation both under normal...
Topics
- 5' Untranslated Regions
- Base Sequence
- Binding Sites
- Glycine-tRNA Ligase
- HEK293 Cells
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Chain Initiation, Translational
- Poliovirus
- Protein Structure, Tertiary