Article
Binding of Glycyl-tRNA synthetase to Mengovirus RNA stimulates translation.
Nucleic acids research - 5 Jan 2026
Droß Fabian, Gödert Tim, Fuchshuber Selena A, Nachev Dimitar V, Andreev Dmitri E, Fricke Markus, Ritsch Muriel, Gerresheim Gesche K, Repp Simeon, Noe Yannic, Rossbach Oliver, Marz Manja, Barth Patrick, Goesmann Alexander, Linne Uwe, Weber Axel, Kracht Michael, Shatsky Ivan N, Niepmann Michael
Abstract excerpt
Picornaviruses are small viruses with a plus-strand RNA genome in which RNA secondary structures bind cellular proteins to support viral translation and replication. Here, we characterize tRNA anticodon stem-loop-like structures in the 5'- and 3' untranslated regions (UTRs) of the RNA of Mengovirus, a member of the Cardiovirus group in the Picornaviridae family. These RNA elements specifically bind cellular...
Topics
- RNA, Viral
- Protein Biosynthesis
- Glycine-tRNA Ligase
- 3' Untranslated Regions
- Binding Sites
- 5' Untranslated Regions
- Nucleic Acid Conformation
- Humans
- Mutation
- Protein Binding
- Picornavirales
- Anticodon