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Article

RNA-Binding Proteins as Regulators of Internal Initiation of Viral mRNA Translation

19 Jan 2022

Abstract excerpt

Viruses are obligate intracellular parasites that depend on the host's protein synthesis machinery for translating their mRNAs. The viral mRNA (vRNA) competes with the host mRNA to recruit the translational machinery, including ribosomes, tRNAs, and the limited eukaryotic translation initiation factor (eIFs) pool. Many viruses utilize non-canonical strategies such as targeting host eIFs and RNA elements known as...

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PMID: 35215780
DOI: 10.3390/v14020188

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