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A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon

9 Jun 2023

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, generates multiple protein-coding, subgenomic RNAs (sgRNAs) from a longer genomic RNA, all bearing identical termini with poorly understood roles in regulating viral gene expression. Insulin and interferon-gamma, two host-derived, stress-related agents, and virus spike protein, induce binding of glutamyl-prolyl-tRNA...

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PMID: 37296097
DOI: 10.1038/s41467-023-39091-3

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