Article
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
Human molecular genetics - 1 Feb 2014
Ehrnhoefer Dagmar E, Skotte Niels H, Ladha Safia, Nguyen Yen T N, Qiu Xiaofan, Deng Yu, Huynh Khuong T, Engemann Sabine, Nielsen Signe M, Becanovic Kristina, Leavitt Blair R, Hasholt Lis, Hayden Michael R
Abstract excerpt
Activation of caspase-6 in the striatum of both presymptomatic and affected persons with Huntington's disease (HD) is an early event in the disease pathogenesis. However, little is known about the role of caspase-6 outside the central nervous system (CNS) and whether caspase activation might play a role in the peripheral phenotypes, such as muscle wasting observed in HD. We assessed skeletal muscle tissue from HD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.